منابع مشابه
Integrons
Integrons are genetic elements first described at the end of the 1980s. Although most integrons were initially described in human clinical isolates, they have now been identified in many non-clinical environments, such as water and soil. Integrons are present in ≈10% of the sequenced bacterial genomes and are frequently linked to mobile genetic elements (MGEs); particularly the class 1 integron...
متن کاملIntegrons and the Origin of Antibiotic Resistance Gene Cassettes
I ntegrons, which are natural genetic engineering platforms, can incorporate open reading frames and convert them to functional genes by ensuring correct expression. Although such integrons play a major role in multidrug resistance phenomena among gram-negative species, similar platforms occur in numerous bacterial species, where they can play other roles. Meanwhile, we have evidence suggesting...
متن کاملIntegrons: past, present, and future.
Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons re...
متن کاملGene cassettes and cassette arrays in mobile resistance integrons.
Gene cassettes are small mobile elements, consisting of little more than a single gene and recombination site, which are captured by larger elements called integrons. Several cassettes may be inserted into the same integron forming a tandem array. The discovery of integrons in the chromosome of many species has led to the identification of thousands of gene cassettes, mostly of unknown function...
متن کاملIntegrons and antibiotic resistance in phylogenetic group B2 Escherichia coli.
It has been reported that Escherichia coli B2 phylogenetic group strains are more susceptible to antibiotics, especially to quinolones, and tend to carry less integrons than other phylogenetic groups in commensal environments. To gain a better understanding of the relationships between antibiotic resistance, integrons, and phylogenetic groups in an environment with high antibiotic selective pre...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2004
ISSN: 1198-743X
DOI: 10.1111/j.1198-743x.2004.00858.x